Budesonid as a means of intraoperative lung protection during coronary bypassing in patients with concomitant chronic obstructive pulmonary disease and coronary heart disease: a pilot study

Lung protection during surgeries with artificial circulation (AC) is a vital task in clinical medicine. The aim . Evaluation of the effectiveness intraoperative administration nebulized budesonide for correcting volume status lungs and oxygen transport patients concomitant coronary heart disease (CHD) chronic obstructive pulmonary (COPD) artery bypass grafting (CABG) (AC). Methods pilot study included 40 CHD COPD who were admitted scheduled CABG AC. first groups consisted 20 underwent low-volume lung ventilation (AVL) inhalation process AC; second group AC according to routine technique AVL off. volemic parameters recorded by transpulmonary thermodilution using Pulsion PiCCO three stages: before onset AC, after its completion one day Results It was established that withdrawal from indices extravascular water (IEWL) decreased 23% increased 24% group. After it, IEWL significantly receiving maximum rise at stage index delivery utilization over time within reference range all patients. consumption did not reach physiologically normal lower limit. level blood fraction (16 12%, respectively) significant decrease oxygenation (240 – 290 c. u.) this cohort 2nd 3rd stages study. duration postoperative longer group, while in-hospital treatment differ groups. Conclusion protective effects combination aerosol therapy manifested permeability capillaries, IEWL, an improvement oxygenating function lungs, number respiratory complications AVL.